VitaScript 5-MTHF 1,000 mcg (60 capsules)


5-MTHF is a useful dietary supplement for those individuals that prefer a high dose active form of folic acid called (6S) 5-MTHF, and for those wishing to support methylation, cellular health and provide a safeguard for folate levels during the child bearing years.


5-MTHF supplies 1,000 mcg of biologically active folate called (6S) 5-methyltetrahydrofolic acid from 2000 mg of Quatrefolic.

Quatrefolic from Gnosis is a new generation of folic acid. It provides folate in the (6S)-5-methyltetrahydrofolate form which is easily utilized and stored in the body.


The terms “Folate” and “folic acid” are often used interchangeably. Folic acid is a member of the B vitamin family and is necessary for methylation reactions in that it is required for the donation or transfer of methyl groups and for donating its own methyl group to homocysteine in order to produce methionine for the production of SAMe, the principle methylating agent in the body. Folate is also required for healthy development of cells, brain function and protection from cell damage.

Folates are normally found in a wide variety of foods. However, they are unstable and susceptible to oxidation and rapidly lose activity during food processing, manufacturing and storage. Common folic acid supplements must be converted to the active form by an enzyme, methylenetetrahydrofolate reductase in order to be absorbed and utilized by the body. In certain populations, the body’s ability to convert folic acid to 5-MTHF by use of this enzyme may be compromised due to genetic differences.

Several conditions such as an enzyme defect, malabsorption, digestive system challenges and poor liver function can lead to a folate deficiency. Lifestyle choices such as smoking, alcohol excess, eating disorders, low vegetable intake and chronic dieting can place individuals at risk for low folate levels. Studies have demonstrated that many individuals are deficient in folate due to poor metabolism of folic acid found in food or supplements.

5-MTHF features the Quatrefolic brand folate which bypasses the need for enzymatic activation, making it readily available to the body.

Folate is a water-soluble essential B vitamin found in many foods, including leafy green vegetables, citrus fruits and beans. Research has established that supplementation with folate before and during the first two months of pregnancy can support proper neurological development in the fetus. Additionally, folate plays a key role in the metabolism of homocysteine. Homocysteine is a sulfur containing amino acid that is created in the body from methionine, an essential amino acid derived solely from dietary intake. High plasma levels of homocysteine appear to injure the vasculature, impairing the functional abilities of endothelial and smooth muscle cells.

Quatrefolic contains only the S isomer of 5-MTHF and has been shown to be the only form of folate to be able to cross the blood-brain barrier. It does not appear to mask the anemia associated with a vitamin B12 deficiency and presents no risk of an accumulation of unmetabolized folic acid in the body.


5-MTHF is a useful dietary supplement for those individuals that prefer a high dose active form of folic acid called (6S) 5-MTHF, and for those wishing to support methylation, cellular health and provide a safeguard for folate levels during the child bearing years.

FORMULA (WW #10342)

One Vegetarian Capsule Contains:

Folate (as [6S]-5-methyltetrahydrofolic acid from 2,000mcg of Quatrefolic [6S]-5-methyltetrahydrofolic acid,glucosamine salt)………………..1000 mcg

Other Ingredients: Vegetable cellulose (capsule), microcrystalline cellulose, vegetarian leucine

This product is vegetarian, gluten and soy-free, and made with non-GMO ingredients.

This product contains NO yeast, gluten, soy protein, milk/dairy, corn, sugar, starch, preservatives, artificial colors or flavors.


As a dietary supplement, adults take 1 capsule daily or as directed by a healthcare professional.


No adverse effects have been reported.


Store in a cool, dry place, away from direct light. Keep out of reach of children.


If pregnant or nursing, consult your healthcare professional before taking.


  1. Scott (2001): Methyltetrahydrofolate: The Superior Alternative to Folic acid. Nutraceuticals in health and disease prevention, 75-90 [Krämer K, Hoppe PP and Packer L, editors]. New York: Marcel Dekker Inc.
  2. Hasselwander, W. Hönlein, L. Schweillert, K. Krömer (2000): 5-Methyltetrahydrofolate: The active form of folic acid. Functional foods 2000.
  3. Smulders, D. Smith, R. Kok, T. Teerlink, D. Swinkels, C. Stehouwer, C. Jabobs (2005): Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: a case for the methylfolate trap. British J. of Haematology, 132, 623-9.
  4. Gutstein, L. Bernstein, L. Levy, G. Wagner (1973): Failure of response to N5-methyltetrahydrofolate in combined folate and B12 deficiency. Evidence in support of the “folate trap” hypothesis. Digestive diseases, Vol. 18 (2), 142-6.
  5. P. Kirke, L. Mills, A. Molloy, l. Brody, V. O’Leary, L. Daly, S. Murray, M. Conley, P. Mayne, O. Smith, J. Scott (2004): Impact of the MTHFR C677T polymorphism on risk of neutral tube defects: case-control study. BMJ, Vol. 328, 1535-6.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.