Saccharomyces Boulardii is a natural, non-pathogenic yeast that has been shown to maintain and restore the healthy ecology of the small and large intestines.
Saccharomyces Boulardii has been shown to be effective through 50 years of usage and numerous research studies. These studies have demonstrated that Saccharomyces Boulardii:
- Helps to maintain the balance of good microorganisms in the gut.
- Keeps the gut functioning well.
- Promotes intestinal health.
- Protects good microorganisms in the gut.
- Improves consistency of bowel movements.
In a 2010 systematic review and meta-analysis of 31 randomized, placebo-controlled treatment arms in 27 trials (encompassing 5029 adult study patients), S. boulardii was found to be significantly efficacious and safe in 84% of those treatment arms. A study also suggested that S. boulardii can be used safely and effectively in children three months and older. A double-blind, randomized, placebo controlled study of children ages 3-59 months produced statistically significant positive results suggesting that S. boulardii may play an important role in supporting normal gastrointestinal function in young children.
Extensively researched and published in European and American peer-reviewed journals, Saccharomyces boulardii has demonstrated several mechanisms of action. These include (1) secretion of a protease that degrades bacterial toxins, inhibiting them from binding to the intestinal brush border, (2) binding of E coli, Salmonella ssp, and other bacteria, preventing these bacteria from adhering to the intestinal epithelium and, possibly, expelling these pathogens from the body via the stool, (3) stimulation of immune cells of the intestinal mucosa, (4) hindrance of the ability of Candida albicans to form filaments and to adhere and form biofilms, and (5) providing support for an increase in fecal short-chain fatty acids, including butyrate.
To put it plainly, S. Boulardii, stimulates immune response in the intestinal mucosa, enhances the integrity of mucosa and enzymatic activity of the intestinal cells, and neutralizes certain bacterial toxins. Since S. Boulardii is a beneficial yeast, it is safe to use during antibiotic therapy.
Saccharomyces Boulardii would be a helpful dietary supplement for individuals wishing to normalize their intestinal gut flora.
As a dietary supplement, adults take one capsule in the morning and one at night or as directed by a healthcare professional.
Keep tightly closed in a cool, dry place. Keep out of reach of children. Does not require refrigeration.
FORMULA (WW #10356)
One vegetarian capsule contains:
Saccharomyces boulardii……………………………….250 mg
(providing 5 billion live organisms)
Other ingredients: Microcrystalline cellulose, vegetable capsule, magnesium stearate (vegetable source), and silicon dioxide.
This product contains NO wheat, gluten, corn, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically-modified organisms (GMOs), artificial colors, artificial sweeteners, or preservatives.
- McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010 May 14;16(18):2202-22
- Vandenplas Y, Brunser O, Szajewska H. Saccharomyces boulardii in childhood. Eur J Pediatr. 2009 Mar; 168(3):253-65. Review
- Can M, Besirbellioglu BA, Avci IY, et al. Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: a prospective study. Med Sci Monit. 2006 Apr; 12(4):119-22.
- Castagliuolo I, Riegler MF, Valenick L, et.al. Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa. Infect Immun. 1999 Jan; 67(1):302-7.
- Im E, Pothoulakis C, Recent advances in Saccharomyces boulardii research. Gastroenterol Clin Biol. 2010 Sep; 34 Suppl 1:562-70. Review.
- Pothoulakis C, Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii. Aliment Pharmacl Ther. 2009 Oct 15;30(8):826-33.
- Schneider SM, Girard-Pipau F, Fillippi J, et.al. Effects of Saccharomyces boulardii on fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition. World J Gastroenterol. 2005 Oct 21;11(39):6165-9.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.